单核细胞增生性李斯特菌脑膜炎免疫应答机制

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王月,王晓娟,关鸿志,王芳,马海畅,秦灵芝,金珂,贾亚珍,周珂珂,李玮.单核细胞增生性李斯特菌脑膜炎免疫应答机制的研究进展[J].国际神经病学神经外科学杂志,,47(4):-.

WANGYue,WANGXiao-Juan,GUANHong-Zhi,WANGFang,MAHai-Chang,QINLing-Zhi,JINKe,JIAYa-Zhen,ZHOUKe-Ke,LIWei.ResearchadvancesinimmuneresponsemechanismofListeriamonocytogenesmeningitis[J].JournalofInternationalNeurologyandNeurosurgery,,47(4):-.

摘要：李斯特菌脑膜炎是单核细胞增生性李斯特菌感染引起的脑膜炎，具有极高的致死率。对李斯特菌病的发病机制的研究目前主要集中在细菌如何跨肠道屏障、胎盘屏障方面。而免疫学机制及炎症通路有待表征。研究发现在感染早期宿主就能识别细菌DNA启动先天性免疫反应，随后引起相应靶细胞分泌炎症因子启动适应性免疫反应。该文从固有性免疫、适应性免疫反应、补体系统等方面综述了单核细胞增生性李斯特脑膜炎发病机制的研究进展。关键词：脑膜炎单核细胞增生性李斯特菌免疫学机制ResearchadvancesinimmuneresponsemechanismofListeriamonocytogenesmeningitisWANGYue1,2,WANGXiao-Juan2,GUANHong-Zhi3,WANGFang2,4,MAHai-Chang2,5,QINLing-Zhi2,JINKe1,2,JIAYa-Zhen1,2,ZHOUKe-Ke1,2,LIWei2Abstract:ListeriamonocytogenesmeningitisiscausedbyinfectionwithListeriamonocytogenesandhasahighmortalityrate.Theresearchonthepathogenesisoflisteriosisiscurrentlyfocusedonhowthebacteriacrosstheintestinalbarrierandtheplacentalbarrier;however,thespecificimmunologicalmechanismsandinflammatorypathwaysinvolvedinthecrossingoftheblood-brainbarrierneedtobecharacterized.ThecurrentstudieshaveshownthatthehostcanrecognizebacterialDNAandinitiateinnateimmuneresponseintheearlystageofinfectionandthencausethecorrespondingtargetcellstosecreteinflammatoryfactorstoinitiateadaptiveimmuneresponse.ThisarticlesummarizestheresearchadvancesinthepathogenesisofListeriamonocytogenesmeningitisfromtheaspectsofinnateimmunity,adaptiveimmuneresponse,and

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